Use this Anti Internal Bacteria aquarium treatment in coldwater or tropical fish in marine or freshwater systems to help to halt bacterial problems and prevent them from spreading. Internal systemic bacterial infections are a common cause of death in aquarium fish, previously only treatable with veterinary prescribed antibiotics. Use this treatment if your fish have swollen eyes, open sores, abdominal swelling, reddening or blood streaks under the skin surface. Or if gills are pale or eroded, fish have sudden loss of appetite or there are unexplained deaths. Pack provides 2 doses and is simple to use.